Small GTPases orchestrate cell-cell communication during collective cell movement
نویسندگان
چکیده
منابع مشابه
Cell-cell communication during collective migration.
Cell motility plays a critical role in many biological and medical processes, including wound healing, morphogenesis, and cancer metastasis (1). Often, this movement is guided by external chemical cues in the form of chemoattractant gradients. These cues consist of diffusive chemoattractant molecules that bind to surface receptors on the cell membrane and activate intracellular signaling pathwa...
متن کاملRho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement
Cell movement is essential during embryogenesis to establish tissue patterns and to drive morphogenetic pathways and in the adult for tissue repair and to direct cells to sites of infection. Animal cells move by crawling and the driving force is derived primarily from the coordinated assembly and disassembly of actin filaments. The small GTPases, Rho, Rac, and Cdc42, regulate the organization o...
متن کاملIntegrating chemotaxis and contact-inhibition during collective cell migration: Small GTPases at work.
For directional cell migration to occur cells must interpret guiding cues present in their environment. Chemotaxis based on negative or positive signals has been long thought as the main driving force of guided cell migration. However during collective cell migration cells do receive information from external signals but also upon interactions with their direct neighbours. These multiple inputs...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2017
ISSN: 2154-1248,2154-1256
DOI: 10.1080/21541248.2017.1366965